USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P07858 USC-OGP 2-DE database:  P07858 P07858 General information about the entry View entry in simple text format Entry name CATB_HUMAN Primary accession number P07858 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Cathepsin B; EC=3.4.22.1; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;. Gene name Name=CTSB Synonyms=CPSB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1230: pI=5.28; Mw=34566 SPOT OGP-1235: pI=5.27; Mw=33325 SPOT OGP-1283: pI=5.35; Mw=25790 Cross-references UniProtKB/Swiss-Prot P07858; CATB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CATB_HUMAN Primary accession number P07858 Secondary accession number(s) B3KQR5 B3KRR5 Q503A6 Q96D87 Sequence was last modified on  June 21, 2005 (version 3) Annotations were last modified on  March 15, 2017 (version 200) Name and origin of the protein Description RecName: Full=Cathepsin B; EC=3.4.22.1; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor; Gene name Name=CTSB Synonyms=CPSB Encoded on Name=CTSB; Synonyms=CPSB Keywords 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Secreted; Signal; Thiol protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M14221; AAA52129.1; -; mRNA EMBL L16510; AAC37547.1; -; mRNA EMBL AK092070; BAG52477.1; -; mRNA EMBL AK075393; BAG52127.1; -; mRNA EMBL CH471157; EAW65630.1; -; Genomic_DNA EMBL BC010240; AAH10240.1; -; mRNA EMBL BC095408; AAH95408.1; -; mRNA EMBL M13230; AAA52125.1; -; mRNA CCDS CCDS5986.1; -; . PIR A26498; KHHUB; . RefSeq NP_001899.1; NM_001908.4; . RefSeq NP_680090.1; NM_147780.3; . RefSeq NP_680091.1; NM_147781.3; . RefSeq NP_680092.1; NM_147782.3; . RefSeq NP_680093.1; NM_147783.3; . RefSeq XP_006716307.1; XM_006716244.2; . RefSeq XP_006716308.1; XM_006716245.2; . RefSeq XP_011542114.1; XM_011543812.2; . RefSeq XP_016868586.1; XM_017013097.1; . RefSeq XP_016868587.1; XM_017013098.1; . RefSeq XP_016868588.1; XM_017013099.1; . RefSeq XP_016868589.1; XM_017013100.1; . UniGene Hs.520898; -; . PDB 1CSB; X-ray; 2.00 A; A/D=80-126 B/E=129-333 PDB; 1GMY; X-ray; 1.90 A A/B/C=79-339 PDB; 1HUC; X-ray; 2.10 A A/C=80-126 B/D=129-333; PDB; 1PBH; X-ray 3.20 A A=18-333; PDB; 2IPP; X-ray 2.15 A A=80-126; B=129-333; PDB; 2PBH X-ray 3.30 A; A=18-333; PDB; 3AI8 X-ray 2.11 A; A/B=78-333; PDB; 3CBJ X-ray 1.80 A; A=74-339; PDB; 3CBK X-ray 2.67 A; A=74-339; PDB; 3K9M X-ray 2.61 A; A/B=80-333; PDB; 3PBH X-ray 2.50 A; A=18-333; PDBsum; 1CSB PDBsum 1GMY; -; . PDBsum 1HUC; -; . PDBsum 1PBH; -; . PDBsum 2IPP; -; . PDBsum 2PBH; -; . PDBsum 3AI8; -; . PDBsum 3CBJ; -; . PDBsum 3CBK; -; . PDBsum 3K9M; -; . PDBsum 3PBH; -; . ProteinModelPortal P07858; -; . SMR P07858; -; . BioGrid 107888; 35; . DIP DIP-42785N; -; . IntAct P07858; 39; . MINT MINT-1397666; -; . STRING 9606.ENSP00000342070; -; . BindingDB P07858; -; . ChEMBL CHEMBL4072; -; . DrugBank DB02108; 2-Aminoethanimidic Acid; . DrugBank DB03329; 2-Pyridinethiol; . DrugBank DB02148; 3-Amino-4-Oxybenzyl-2-Butanone; . DrugBank DB02685; 3-Methylphenylalanine; . DrugBank DB03588; Diphenylacetic Acid; . DrugBank DB02855; N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline; . DrugBank DB04126; N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane; . GuidetoPHARMACOLOGY 2343; -; . MEROPS C01.060; -; . iPTMnet P07858; -; . PhosphoSitePlus P07858; -; . SwissPalm P07858; -; . BioMuta CTSB; -; . DMDM 68067549; -; . SWISS-2DPAGE P07858; -; . UCD-2DPAGE P07858; -; . EPD P07858; -; . MaxQB P07858; -; . PaxDb P07858; -; . PeptideAtlas P07858; -; . PRIDE P07858; -; . TopDownProteomics P07858; -; . DNASU 1508; -; . Ensembl ENST00000345125; ENSP00000342070; ENSG00000164733; . Ensembl ENST00000353047; ENSP00000345672; ENSG00000164733; . Ensembl ENST00000453527; ENSP00000409917; ENSG00000164733; . Ensembl ENST00000530640; ENSP00000435105; ENSG00000164733; . Ensembl ENST00000531089; ENSP00000433215; ENSG00000164733; . Ensembl ENST00000533455; ENSP00000432244; ENSG00000164733; . Ensembl ENST00000534510; ENSP00000434217; ENSG00000164733; . GeneID 1508; -; . KEGG hsa:1508; -; . UCSC uc003wun.4; human; . CTD 1508; -; . DisGeNET 1508; -; . GeneCards CTSB; -; . H-InvDB HIX0007320; -; . HGNC HGNC:2527; CTSB; . HPA CAB000457; -; . HPA HPA018156; -; . MIM 116810; gene; . neXtProt NX_P07858; -; . OpenTargets ENSG00000164733; -; . PharmGKB PA27027; -; . eggNOG KOG1543; Eukaryota; . eggNOG COG4870; LUCA; . GeneTree ENSGT00780000121937; -; . HOGENOM HOG000241341; -; . HOVERGEN HBG003480; -; . InParanoid P07858; -; . KO K01363; -; . OMA EDMLTCC; -; . OrthoDB EOG091G094Z; -; . PhylomeDB P07858; -; . TreeFam TF314576; -; . BRENDA 3.4.22.1; 2681; . Reactome R-HSA-1442490; Collagen degradation; . Reactome R-HSA-1679131; Trafficking and processing of endosomal TLR; . Reactome R-HSA-2022090; Assembly of collagen fibrils and other multimeric structures; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-6798695; Neutrophil degranulation; . ChiTaRS CTSB; human; . EvolutionaryTrace P07858; -; . GeneWiki Cathepsin_B; -; . GenomeRNAi 1508; -; . PMAP-CutDB P07858; -; . PRO PR:P07858; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000164733; -; . CleanEx HS_CTSB; -; . ExpressionAtlas P07858; baseline and differential; . Genevisible P07858; HS; . GO GO:0036021; C:endolysosome lumen; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005622; C:intracellular; TAS:ProtInc; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0005764; C:lysosome; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IDA:HPA; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0005518; F:collagen binding; IDA:BHF-UCL; . GO GO:0004197; F:cysteine-type endopeptidase activity; IDA:BHF-UCL; . GO GO:0008234; F:cysteine-type peptidase activity; IDA:UniProtKB; . GO GO:0008233; F:peptidase activity; IDA:BHF-UCL; . GO GO:0043394; F:proteoglycan binding; IPI:BHF-UCL; . GO GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome; . GO GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB; . GO GO:0030574; P:collagen catabolic process; IDA:BHF-UCL; . GO GO:0046697; P:decidualization; IEA:Ensembl; . GO GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0006508; P:proteolysis; IDA:UniProtKB; . GO GO:0051603; P:proteolysis involved in cellular protein catabolic process; IDA:BHF-UCL; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0050790; P:regulation of catalytic activity; IEA:InterPro; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . GO GO:0046718; P:viral entry into host cell; IEA:Ensembl; . InterPro IPR025661; Pept_asp_AS; . InterPro IPR000169; Pept_cys_AS; . InterPro IPR025660; Pept_his_AS; . InterPro IPR013128; Peptidase_C1A; . InterPro IPR000668; Peptidase_C1A_C; . InterPro IPR015643; Peptidase_C1A_cathepsin-B; . InterPro IPR012599; Propeptide_C1A; . PANTHER PTHR12411; PTHR12411; 1; . PANTHER PTHR12411:SF480; PTHR12411:SF480; 1; . Pfam PF00112; Peptidase_C1; 1; . Pfam PF08127; Propeptide_C1; 1; . PRINTS PR00705; PAPAIN; . SMART SM00645; Pept_C1; 1; . PROSITE PS00640; THIOL_PROTEASE_ASN; 1; . PROSITE PS00139; THIOL_PROTEASE_CYS; 1; . PROSITE PS00639; THIOL_PROTEASE_HIS; 1; .

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